Catalog No.: PC-38665Not For Human Use, Lab Use Only.
HPK inhibitor compound 1 is an allosteric, inactive conformation-selective HPK1 inhibitor, binds to unphosphorylated HPK1 and >24-fold more potently than active HPK1.
HPK inhibitor compound 1 is an allosteric, inactive conformation-selective HPK1 inhibitor, binds to unphosphorylated HPK1 and >24-fold more potently than active HPK1.
HPK inhibitor compound 1 is not competitive with ATP, and is highly selective against kinases critical for T cell signaling.
HPK inhibitor compound 1 does not bind to the isolated HPK1 kinase domain alone but requires other domains, attenuates kinase autophosphorylation by binding to a pocket consisting of residues within and outside of the kinase domain.
