HS-276 | TAK1 inhibitor | Probechem Biochemicals

Chemical Structure : HS-276

CAS No.: 2767422-72-8

HS-276 (HS276)

Catalog No.: PC-73239Not For Human Use, Lab Use Only.

HS-276 is a potent, highly selective and orally bioavailable TAK1 inhibitor with Ki of 2.5 nM.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$428	In stock
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Biological Activity

HS-276 is a potent, highly selective and orally bioavailable TAK1 inhibitor with Ki of 2.5 nM.
HS-276 showed significant inhibition of TNF-mediated cytokine profiles in vitro (IC50=138 nM) and in vivo.
HS-276 demonstrated significant attenuation of arthritic-like symptoms in the CIA mouse model of inflammatory RA.

Physicochemical Properties

M.Wt	419.529
Formula	C24H29N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(piperidin-1-ylmethyl)-1-propyl-1H-benzo[d]imidazol-2-yl)isophthalamide

References

1. Scott Scarneo, et al. ACS Chem Biol. 2022 Mar 18;17(3):536-544.

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HS-276 (HS276)

Biological Activity

Physicochemical Properties

References

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