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Chemical Structure : HSD-016
Catalog No.: PC-35574Not For Human Use, Lab Use Only.
HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.
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HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.
HSD-016 significantly inhibits the 11β-HSD1 activity in mice 3T3-L1 adipocytes with IC50 of 362 nM.
HSD-016 (HSD016) has entered phase I clinical trials for the treatment of diabetes.
| M.Wt | 514.459 | |
| Formula | C21H21F7N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wan ZK, et al. J Org Chem. 2011 Sep 2;76(17):7048-55.
2. Hong SP, et al. Eur J Pharmacol. 2018 Aug 7. pii: S0014-2999(18)30450-3.
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