Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : HSD-016
Catalog No.: PC-35574Not For Human Use, Lab Use Only.
HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively.
HSD-016 significantly inhibits the 11β-HSD1 activity in mice 3T3-L1 adipocytes with IC50 of 362 nM.
HSD-016 (HSD016) has entered phase I clinical trials for the treatment of diabetes.
| M.Wt | 514.459 | |
| Formula | C21H21F7N2O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Wan ZK, et al. J Org Chem. 2011 Sep 2;76(17):7048-55.
2. Hong SP, et al. Eur J Pharmacol. 2018 Aug 7. pii: S0014-2999(18)30450-3.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
