Chemical Structure : HSK21542
CAS No.:
2269511-95-5
HSK21542
(Anrikefon, HSK-21542)
Catalog No.: PC-23826Not For Human Use, Lab Use Only.
Anrikefon (HSK21542) is a potent, selective and peripherally-restricted kappa opioid receptor (KOR) agonist, prevents [3H]diprenorphine binding to KOR with IC50 of 0.54 nM, and binding Kd of 0.068 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Anrikefon (HSK21542) is a potent, selective and peripherally-restricted kappa opioid receptor (KOR) agonist, prevents [3H]diprenorphine binding to KOR with IC50 of 0.54 nM, and binding Kd of 0.068 nM.
HSK21542 significantly inhibits forskolin-induced cAMP accumulation in HEK-293 cells that stably expressed human κ opioid receptor with an EC50 of 2.41 pM.
HSK21542 displays no significant affinity against a broad panel of receptors, ion channels, transporters and enzymes, including MOR and DOR.
HSK21542 significantly inhibits acetic acid-, hindpaw incision- or chronic constriction injury-induced pain-related behaviors in animal models of pain
Physicochemical Properties
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M.Wt
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703.93
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Formula
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C39H57N7O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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7-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-2-acetyl-2,7-diazaspiro (3.5)nonane
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References
1. Wang X, et al. Front Pharmacol. 2021 Nov 16;12:773204.
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