HT-0411 |CAS:947539-81-3 Probechem Biochemicals

Chemical Structure : HT-0411

HT-0411 (HT0411)

Catalog No.: PC-61488Not For Human Use, Lab Use Only.

HT-0411 is a selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 1.4 uM, with less potency for MT-1 and MT-2.

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Biological Activity

HT-0411 is a selective monoamine oxidase B (MAO-B) inhibitor with IC50 of 1.4 uM, with less potency for MT-1 and MT-2.
HT-0411 causes CREB activation in vitro, improves 24-hour memory in rodents in a contextual fear conditioning model.

Physicochemical Properties

M.Wt	303.303
Formula	C12H12F3N3OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-dimethyl-5-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-carboxamide

References

1. Kaplan A, et al. ACS Chem Neurosci. 2017 Dec 20;8(12):2746-2758.

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HT-0411 (HT0411)

Biological Activity

Physicochemical Properties

References

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