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Chemical Structure : HT-0712
Catalog No.: PC-63088Not For Human Use, Lab Use Only.
HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A.
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HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A.
HT-0712 (IPL-455903) facilitates expression of a CRE-luciferase reporter gene and expression of the CREB target-gene somatostatin in SK-N-MC neuroblastoma cells,.
HT-0712 (IPL-455903) bolishes the long-term memory defect of CBP+/- mice, enhances long-term memory formation in normal young mice at brain concentrations similar to those found to increase CRE-mediated gene expression in hippocampal neurons.
| M.Wt | 393.53 | |
| Formula | C25H31NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Peters M, et al. Neuropsychopharmacology. 2014 Dec;39(13):2938-48.
2. MacDonald E, et al. Neurorehabil Neural Repair. 2007 Nov-Dec;21(6):486-96.
3. Bourtchouladze R, et al. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10518-22.
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