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Chemical Structure : HT105
Catalog No.: PC-35798Not For Human Use, Lab Use Only.
HT105 (HT-105) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM.
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HT105 (HT-105) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM.
HT105 exerted a potent cytotoxic effect against a large panel of tumor cell lines, unlike DB550, HT105 possesses off-target effects responsible for triggering a cell-death program in tumor cells.
| M.Wt | 958.154 | |
| Formula | C42H67N15O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Poissonnier A, et al. Nat Chem Biol. 2018 Dec;14(12):1079-1089.
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