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Chemical Structure : HTH-01-091
Catalog No.: PC-61763Not For Human Use, Lab Use Only.
HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM.
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HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM.
HTH-01-091 displays no significant activity for PIK3CA, mTOR, GSK3A and CDK7 (IC50>600 nM); exhibits substantially improved kinome selectivity in comparison with OTSSP167.
HTH-01-091 induces MELK degradation, but demonstrates poor antiproliferative effects in basal-like breast cancer cell lines.
| M.Wt | 499.436 | |
| Formula | C26H28Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.
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