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HTL0039732

Chemical Structure : HTL0039732

CAS No.: 2639366-75-7

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HTL0039732 (HTL-0039732)

Catalog No.: PC-27537Not For Human Use, Lab Use Only.

HTL0039732 is a potent, selective and orally bioavailable E-type prostanoid receptor 4 (EP4) antagonist, blocks signalling through prostaglandin E2 receptor EP4, enhances immune response against tumours that typically resist current immunotherapies.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HTL0039732 is a potent, selective and orally bioavailable E-type prostanoid receptor 4 (EP4) antagonist, blocks signalling through prostaglandin E2 receptor EP4, enhances immune response against tumours that typically resist current immunotherapies.

    Physicochemical Properties

    M.Wt 435.44
    Formula C23H24F3NO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Benzoic acid, 4-[1-[[(2R)-3-methyl-1-oxo-2-[[4-(trifluoromethyl)phenyl]methoxy]butyl]amino]cyclopropyl]-

    References

    1. Astley D, et al. Bioanalysis. 2026 Aug 6:1-10. doi: 10.1080/17576180.2026.2712785.

    2. Dan Astley, et al. Cancer Res (2026) 86 (8_Supplement): LB469.

    3. Patent WO2021069927 A1 2021-04-15.

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