HTL22562 | CGRP inhibitor | Probechem Biochemicals

Chemical Structure : HTL22562

HTL22562 (HTL-22562)

Catalog No.: PC-24984Not For Human Use, Lab Use Only.

HTL22562 is a highly potent, selective, metabolically stable antagonist of calcitonin gene-related peptide (CGRP) receptor with pKi of 10.5 (human CGRP).

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Biological Activity

HTL22562 is a highly potent, selective, metabolically stable antagonist of calcitonin gene-related peptide (CGRP) receptor with pKi of 10.5 (human CGRP).

Physicochemical Properties

M.Wt	763.90
Formula	C40H49N11O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-carboxamide

References

1. Sarah J Bucknell, et al. J Med Chem. 2020 Jul 23;63(14):7906-7920.

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HTL22562 (HTL-22562)

Biological Activity

Physicochemical Properties

References

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