HTS01037 is a highly potent ligand of adipocyte fatty acid binding protein (A-FABP/aP2, FABP4) with Ki of 0.67 uM.
HTS01037 competes with fatty acids for functional binding in the ligand-binding cavity of A-FABP/aP2, antagonizes the protein-protein interaction of A-FABP/aP2 with hormone sensitive lipase in cultured C8PA lipocytes at 10 uM.
HTS01037 inhibits lipolysis in 3T3L1 adipocytes and reduces lipopolysaccharide-stimulated inflammation in bone marrow-derived macrophages.
