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Chemical Structure : HTS 01037
CAS No.: 682741-29-3
Catalog No.: PC-61186Not For Human Use, Lab Use Only.
HTS01037 is a highly potent ligand of adipocyte fatty acid binding protein (A-FABP/aP2) with Ki of 0.67 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $338 | In stock | |
| 100 mg | Get quote |
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HTS01037 is a highly potent ligand of adipocyte fatty acid binding protein (A-FABP/aP2) with Ki of 0.67 uM.
HTS 01037 competes with fatty acids for functional binding in the ligand-binding cavity of A-FABP/aP2, antagonizes the protein-protein interaction of A-FABP/aP2 with hormone sensitive lipase in cultured C8PA lipocytes at 10 uM.
HTS 01037 inhibits lipolysis in 3T3L1 adipocytes and reduces lipopolysaccharide-stimulated inflammation in bone marrow-derived macrophages.
| M.Wt | 337.364 | |
| Formula | C14H11NO5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
[2,2'-Bithiophene]-5-carboxylic acid, 4-[(3-carboxy-1-oxo-2-propenyl)amino]-, 5-methyl ester (9CI) |
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1. Hertzel AV, et al. J Med Chem. 2009 Oct 8;52(19):6024-31.
2. Steen KA, et al. Mol Cell Biol. 2017 Jan 4;37(2). pii: e00282-16.
3. Boss M, et al. Atherosclerosis. 2015 Jun;240(2):424-30.
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