HW161023

Chemical Structure : HW161023

Catalog No.: PC-23576Not For Human Use, Lab Use Only.

HW161023 is a potent, selective AAK1 inhibitor with IC50 of 5.4 nM.

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Biological Activity

HW161023 is a potent, selective AAK1 inhibitor with IC50 of 5.4 nM.
HW161023 shows high selectivity in 225 kinase panel.
HW161023 (10 mg/kg; p.o.) reduced mechanical hyperalgesia in CCI rats.

Physicochemical Properties

M.Wt	374.44
Formula	C20H24F2N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-((8-(2-(difluoromethyl)pyridin-4-yl)imidazo[1,2-a]pyridin-5-yl)oxy)-2,4-dimethylpentan-2-amine

References

1. Jinping Li, et al. Bioorg Med Chem Lett. 2024 Dec 1:114:130012.

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HW161023

Biological Activity

Physicochemical Properties

References

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