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HW201877

Chemical Structure : HW201877

CAS No.: 2927452-83-1

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HW201877 (HW-201877)

Catalog No.: PC-24859Not For Human Use, Lab Use Only.

HW201877 is a potent, selective and orally active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with IC50 of 3.6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HW201877 is a potent, selective and orally active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with IC50 of 3.6 nM.
    HW201877 exhibits robust cellular efficacy in elevating PGE2 levels in A549 cells (4.8-fold increase vs control).
    HW201877 (0.5, 1.0, or 2.0 mg/kg, BID) marked reductions in pulmonary fibrosis scores, achieving comparable therapeutic efficacy in a bleomycin-induced rat pulmonary fibrosis model.

    Physicochemical Properties

    M.Wt 440.45
    Formula C22H22F2N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-[(1aS,7bR)-6-(4,4-difluoropiperidine-1-carbonyl)-1,1a,2,7b-tetrahydro-3H-cyclopropa[c][1,8]naphthyridin-3-yl]-2-methyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

    References

    1. Qun Li, et al. J Med Chem. 2025 Jun 26. doi: 10.1021/acs.jmedchem.5c01361.

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