Chemical Structure : HZS60
CAS No.:
3027529-88-7
HZS60
(HZS-60)
Catalog No.: PC-23906Not For Human Use, Lab Use Only.
HZS60 is a specific NMDAR/TRPM4 interaction interface inhibitor, displays significant neuroprotective effects against both NMDA and oxygen-glucose deprivation/reoxygenation-induced ischemic injury in primary neurons.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HZS60 is a specific NMDAR/TRPM4 interaction interface inhibitor, displays significant neuroprotective effects against both NMDA and oxygen-glucose deprivation/reoxygenation-induced ischemic injury in primary neurons.
HZS60 at both 10 μM and 100 μM showed no effect on calcium-activated TRPM4 channel activity.
HZS60 boosted NMDAR-mediated downstream signaling in responses to NMDA treatment in primary neurons, inhibited OGD/R-induced decrease in phosphorylation of ERK, CREB, CaMKII, and Akt levels
HZS60 eliminated NMDA-induced mitochondrial dysfunction in primary neurons.
HZS60 (ig, 25 mg/kg) reduced neuronal damage in the penumbra of cerebral brain of mice after I/R injury.
HZS60 (ig, 25 mg/kg) disrupted the N/T interaction in mice after ischemic stroke.
HZS60 (ig, 25 mg/kg) treatment inhibited microglial activation in the MCAO-treated mice.
Physicochemical Properties
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M.Wt
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253.30
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Formula
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C13H17F2N3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(1-((2-Aminoethyl)(ethyl)amino)ethyl)-2,4-difluorobenzonitrile
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References
1. Meiling Sun, et al. J Med Chem. 2025 Jan 2. doi: 10.1021/acs.jmedchem.4c02772.
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