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Chemical Structure : Helenalin
Catalog No.: PC-62417Not For Human Use, Lab Use Only.
Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.
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Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway; ablates p65 DNA-binding ability, exhibits low micromolar inhibition of induced NF-κB signaling (53.7±14.1% NF-κB activity at 2.5 uM); suppresses cell proliferation and promotes apoptosis in cultured fibroblasts.
| M.Wt | 262.305 | |
| Formula | C15H18O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Widen JC, et al. ACS Chem Biol. 2017 Jan 20;12(1):102-113.
2. Chen S, et al. Cell Death Dis. 2017 Mar 30;8(3):e2710.
3. Lim CB, et al. BMC Complement Altern Med. 2012 Jul 11;12:93.
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