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Helenalin

Chemical Structure : Helenalin

CAS No.: 6754-13-8

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Helenalin (NSC 85236)

Catalog No.: PC-62417Not For Human Use, Lab Use Only.

Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.

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    Biological Activity

    Helenalin (NSC 85236) is a sesquiterpene lactone that covalently targets Cys38 on p65 transcription factor in the canonical NF-κB signaling pathway.
    Helenalin ablates p65 DNA-binding ability, exhibits low micromolar inhibition of induced NF-κB signaling (53.7±14.1% NF-κB activity at 2.5 uM).
    Helenalin suppresses cell proliferation and promotes apoptosis in cultured fibroblasts.

    Physicochemical Properties

    M.Wt 262.305
    Formula C15H18O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,3aS,4S,4aR,7aR,8R,9,9aR-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-azuleno[6,5-b]furan-2,5-dione

    References

    1. Widen JC, et al. ACS Chem Biol. 2017 Jan 20;12(1):102-113.

    2. Chen S, et al. Cell Death Dis. 2017 Mar 30;8(3):e2710.

    3. Lim CB, et al. BMC Complement Altern Med. 2012 Jul 11;12:93.

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