Herboxidiene | SF3B inhibitor | Probechem Biochemicals

Chemical Structure : Herboxidiene

Herboxidiene (GEX1A, TAN-1609)

Catalog No.: PC-62862Not For Human Use, Lab Use Only.

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Biological Activity

Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome.
Herboxidiene inhibits the pre-mRNA splicing of p27, targets SAP155 protein, a subunit of SF3b responsible for pre-mRNA splicing.

Physicochemical Properties

M.Wt	438.61
Formula	C25H42O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2R,5S,6S)-6-((2E,4E,6S)-7-((1R,2R)-2-((3R,4R)-4-hydroxy-3-methoxypentan-2-yl)-1-methylcyclopropyl)-6-methylhepta-2,4-dien-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)acetic acid

References

1. Ghosh AK, et al. Org Biomol Chem. 2016 Jun 21;14(23):5263-71.

2. AlShareef S, et al. BMC Genomics. 2017 Mar 27;18(1):260.

3. Hasegawa M, et al. ACS Chem Biol. 2011 Mar 18;6(3):229-33.

Herboxidiene (GEX1A, TAN-1609)

Biological Activity

Physicochemical Properties

References

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