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Chemical Structure : Herboxidiene
Catalog No.: PC-62862Not For Human Use, Lab Use Only.
Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome.
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Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome.
Herboxidiene inhibits the pre-mRNA splicing of p27, targets SAP155 protein, a subunit of SF3b responsible for pre-mRNA splicing.
| M.Wt | 438.61 | |
| Formula | C25H42O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ghosh AK, et al. Org Biomol Chem. 2016 Jun 21;14(23):5263-71.
2. AlShareef S, et al. BMC Genomics. 2017 Mar 27;18(1):260.
3. Hasegawa M, et al. ACS Chem Biol. 2011 Mar 18;6(3):229-33.
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