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Chemical Structure : HuR inhibitor KH-3
Catalog No.: PC-72480Not For Human Use, Lab Use Only.
HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.
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HuR inhibitor KH-3 is a small molecule, selective inhibitior of HuR function with Ki of 0.83 and 0.72 uM in FP and AlphaLISA assays, respectively.
KH-3 potently inhibits breast cancer cell growth in vitro and in vivo.
KH-3 inhibits breast cancer cell invasion in vitro as well as delays initiation of lung colonies and improves mouse survival in an experimental metastasis model in vivo.
KH-3 suppresses breast cancer cell invasion by disrupting HuR-FOXQ1 mRNA interaction.
Inhibition of HuR with KH-3 yielded a significant reduced in the progression of pathological cardiac hypertrophy in a transverse aortic constriction model.
| M.Wt | 430.537 | |
| Formula | C21H22N2O4S2 | |
| Appearance | Solid | |
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1. Xiaoqing Wu, et al. Commun Biol. 2020 Apr 24;3(1):193.
2. Simeng Liu, et al. Clin Sci (Lond). 2020 Jun 26;134(12):1433-1448.
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