Human C53 peptide

Chemical Structure : Human C53 peptide

Catalog No.: PC-72559Not For Human Use, Lab Use Only.

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Biological Activity

Human C53 peptide (C53, pGC-B activator C53) is a novel potent, selective particulate guanylyl cyclase B (pGC-B) activator, activates pGC-B/cGMP signaling pathway, and enhances cGMP generating actions.
C53 is highly resistant to NEP degradation and has less interaction with NPRC compared to CNP in vitro.
C53 activates the protective pGC-B/cGMP signaling pathway and possesses enhanced cGMP generating actions.
C53 inhibits fibroblast proliferation chronically and suppresses the differentiation of fibroblasts to myofibroblasts.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Solubility
Chemical Name/SMILES

References

1. Yang Chen, et al. J Mol Cell Cardiol. 2019 May;130:140-150.

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