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HyT-S7

Chemical Structure : HyT-S7

CAS No.: 3020773-13-8

HyT-S7

Catalog No.: PC-24823Not For Human Use, Lab Use Only.

HyT-S7 is a first-in-class hydrophobic tagging-based degrader of HBV core protein (HBC), exhibits potent inhibitory activity (EC50=0.46 uM, reduction of HBV DNA in HepAD38 cells) and degradation ability (DC50=3.02 uM), binds to HBC with SPR KD of 0.78 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HyT-S7 is a first-in-class hydrophobic tagging-based degrader of HBV core protein (HBC), exhibits potent inhibitory activity (EC50=0.46 uM, reduction of HBV DNA in HepAD38 cells) and degradation ability (DC50=3.02 uM), binds to HBC with SPR KD of 0.78 uM.
HyT-S7 degraded HBC through the autophagy pathway.
HyT-S7 exhibited remarkable degradation activity against 11 CpAMs-resistant mutant HBC (P25A, P25G, D29L, D29W, T33N, I105F, I105W, I105Y, T109A, V124W, and V124F).

Physicochemical Properties

M.Wt 708.77
Formula C34H40F4N4O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((4-(2-(2-(2-(adamantan-1-yl)acetamido)ethoxy)acetamido)piperidin-1-yl)sulfonyl)-4-fluoro-N-(3,4,5-trifluorophenyl)benzamide

References

1. Shujing Xu, et al. Acta Pharm Sin B. 2025 Apr;15(4):2170-2196.

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