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Chemical Structure : Hycanthone
CAS No.: 3105-97-3
Catalog No.: PC-21907Not For Human Use, Lab Use Only.
Hycanthone is a thioxanthenone DNA intercalator, inhibits RNA synthesis as well as the DNA topoisomerases I and II, inhibits apurinic endonuclease 1 (APE1) incision of depurinated plasmid DNA with IC50 of 80 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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Hycanthone is a thioxanthenone DNA intercalator, inhibits RNA synthesis as well as the DNA topoisomerases I and II, inhibits apurinic endonuclease 1 (APE1) incision of depurinated plasmid DNA with IC50 of 80 nM.
Hycanthone shows direct protein binding for APE1 with Kd of 10 nM.
Hycanthone is a bioactive metabolite of Lucanthone (Cat# PC-60602).
| M.Wt | 340.49 | |
| Formula | C20H24N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one |
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1. Radin DP, J Pharmacol Exp Ther. 2024 Jan 31:JPET-AR-2023-002021.
2. Naidu MD, et al. PLoS One. 2011;6(9):e23679.
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