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IAA-94

Chemical Structure : IAA-94

CAS No.: 54197-31-8

IAA-94 (IAA94)

Catalog No.: PC-43155Not For Human Use, Lab Use Only.

IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM.

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Biological Activity

IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of epithelial chloride channels that binds channels in bovine kidney cortex microsomes with Ki of 1 uM.
IAA-94 significantly suppresses IGF-I-induced VSMC proliferation, also blocks cell swelling evoked glutamate release from primary microglia and MLS-9 cells.
IAA-94 effectively reduces IFNgamma-induced NO production in microglial BV2 cells.

Physicochemical Properties

M.Wt 357.2284
Formula C17H18Cl2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Acetic acid, 2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-

References

1. Landry DW, et al. J Gen Physiol. 1987 Dec;90(6):779-98.

2. Cheng G, et al. Cardiovasc Res. 2007 Jan 1;73(1):198-207.

3. Schlichter LC, et al. Channels (Austin). 2011 Mar-Apr;5(2):128-37.

4. Kjaer K, et al. Brain Res. 2009 Jul 24;1281:15-24.

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