IACS-4619 (IACS4619)

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Chemical Structure : IACS-4619

Catalog No.: PC-63192Not For Human Use, Lab Use Only.

IACS-4619 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.

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Biological Activity

IACS-4619 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.
IACS-4619 shows no off-target kinase activity in a panel of 97 kinases.
IACS-4619 exhibits excellent cell permeability and good metabolic stability in microsomes.
IACS-4619 is an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.

Physicochemical Properties

M.Wt	195.266
Formula	C10H17N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methyl-4-(neopentyloxy)pyrimidin-2-amine

References

1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.

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