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Chemical Structure : IACS-4759
Catalog No.: PC-62705Not For Human Use, Lab Use Only.
IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.
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IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.
IACS-4759 shows no off-target kinase activity in a panel of 97 kinases.
IACS-4759 exhibits excellent cell permeability and good metabolic stability in microsomes.
IACS-4759 is an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.
| M.Wt | 211.265 | |
| Formula | C10H17N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.
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