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IACS-4759

Chemical Structure : IACS-4759

CAS No.: 1884209-99-7

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IACS-4759 (IACS4759)

Catalog No.: PC-62705Not For Human Use, Lab Use Only.

IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IACS-4759 is a potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.
IACS-4759 shows no off-target kinase activity in a panel of 97 kinases.
IACS-4759 exhibits excellent cell permeability and good metabolic stability in microsomes.
IACS-4759 is an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.

Physicochemical Properties

M.Wt 211.265
Formula C10H17N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((2-amino-5-methylpyrimidin-4-yl)oxy)-2,2-dimethylpropan-1-ol

References

1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.

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