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Chemical Structure : ICA-105574
CAS No.: 316146-57-3
Catalog No.: PC-60832Not For Human Use, Lab Use Only.
ICA-105574 is a potent and efficacious hERG channel activator steeply potentiates current amplitudes more than 10-fold with EC50 of 0.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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ICA-105574 is a potent and efficacious hERG channel activator steeply potentiates current amplitudes more than 10-fold with EC50 of 0.5 uM.
ICA-105574 produces comparatively small hyperpolarizing shifts (up to 11 mV) in the voltage-dependence of channel activation and a 2-fold slowing of channel deactivation.
ICA-105574 enhances IKr current with very high potency by removing the channel inactivation, prevents ventricular arrhythmias in intact guinea-pig hearts caused by IKr and IKs inhibitors.
ICA-105574 has more efficient antiarrhythmic activity than NS1643.
| M.Wt | 334.331 | |
| Formula | C19H14N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-nitro-N-(4-phenoxyphenyl) benzamide |
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1. Gerlach AC, et al. Mol Pharmacol. 2010 Jan;77(1):58-68.
2. Garg V, et al. Mol Pharmacol. 2011 Oct;80(4):630-7.
3. Meng J, et al. Eur J Pharmacol. 2013 Oct 15;718(1-3):87-97.
4. Garg V, et al. Mol Pharmacol. 2013 Apr;83(4):805-13.
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