ICA-105574 is a potent and efficacious hERG channel activator steeply potentiates current amplitudes more than 10-fold with EC50 of 0.5 uM.
ICA-105574 produces comparatively small hyperpolarizing shifts (up to 11 mV) in the voltage-dependence of channel activation and a 2-fold slowing of channel deactivation.
ICA-105574 enhances IKr current with very high potency by removing the channel inactivation, prevents ventricular arrhythmias in intact guinea-pig hearts caused by IKr and IKs inhibitors.
ICA-105574 has more efficient antiarrhythmic activity than NS1643.
Physicochemical Properties
M.Wt
334.331
Formula
C19H14N2O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3-nitro-N-(4-phenoxyphenyl) benzamide
References
1. Gerlach AC, et al. Mol Pharmacol. 2010 Jan;77(1):58-68.
2. Garg V, et al. Mol Pharmacol. 2011 Oct;80(4):630-7.
3. Meng J, et al. Eur J Pharmacol. 2013 Oct 15;718(1-3):87-97.
4. Garg V, et al. Mol Pharmacol. 2013 Apr;83(4):805-13.
