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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Potassium Channel-ICA-27243
ICA-27243

Chemical Structure : ICA-27243

CAS No.: 325457-89-4

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ICA-27243 (ICA27243;ICA-027243)

Catalog No.: PC-60824Not For Human Use, Lab Use Only.

ICA-27243 (ICA-207243) is a potent, selective KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.38 uM.

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25 mg $188 In stock
50 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ICA-27243 (ICA-207243) is a potent, selective KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.38 uM.
ICA-27243 enhances both (86)Rb(+) efflux (EC50= 0.2 microM) and whole-cell currents in CHO cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC50= 0.4 microM).
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5 and is selective over a wide range of neurotransmitter receptors and ion channels such as voltage-dependent sodium channels and GABA-gated chloride channels.
ICA-27243 (1-10 microM) reversibly suppresses seizure-like activity in an ex vivo hippocampal slice model of epilepsy and demonstrates in vivo anticonvulsant activity (ED(50) = 8.4 mg/kg) in the mouse maximal electroshock epilepsy model.

Physicochemical Properties

M.Wt 268.648
Formula C12H7ClF2N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide

References

1. Amato G, et al. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

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