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ICT12035

Chemical Structure : ICT12035

CAS No.: 1355994-75-0

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ICT12035 (AZ2158, AZ-2158, ICT-12035)

Catalog No.: PC-72082Not For Human Use, Lab Use Only.

ICT12035 (AZ2158) is a potent, selective formylpeptide receptor-1 (FPR1) antagonist with IC50 of 30 nM in calcium mobilisation assays (100 nM fMLF).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ICT12035 (AZ2158) is a potent, selective formylpeptide receptor-1 (FPR1) antagonist with IC50 of 30 nM in calcium mobilisation assays (100 nM fMLF).
    ICT12035 is selective (> 100 fold versus FPR2), and non-cytotoxic (cell viability above 95 ± 5% at 100 uM).
    ICT12035 reduces fMLF-induced increases in proliferation in in U87-MG cells, which is a more potent agonist of FPR1 than ANXA1.
    ICT12035 modulates growth of U87-MG xenotransplanted tumour in mice.

    Physicochemical Properties

    M.Wt 490.663
    Formula C25H38N4O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((S)-3,3-dimethylbutan-2-yl)-1-((1s,4R)-4-methoxycyclohexyl)-3-methyl-5-((4-methylphenyl)sulfonamido)-1H-pyrazole-4-carboxamide

    References

    1. Djevdet S Ahmet, et al. Sci Rep. 2020 Oct 14;10(1):17249.

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