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Chemical Structure : IDH305
CAS No.: 1628805-46-8
Catalog No.: PC-60164Not For Human Use, Lab Use Only.
IDH 305 (IDH305) is a potent, selective, brain penetrant mutant IDH1 inhibitor with IC50 of 18 and 28 nM for IDH1 R132H and R132C.
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|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
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| 100 mg | Get quote |
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IDH305 (IDH-305) is a potent, selective, brain penetrant mutant IDH1 inhibitor with IC50 of 18 and 28 nM for IDH1 R132H and R132C.
IDH305 exhibits >200 fold selectivity over WT IDH1 (IC50=6.14 uM), and no activtiy against IDH2 mutants.
IDH305 inhibits EGF-independent proliferation of HCT116-IDH1R132H+/- cells with IC50 of 20 nM.
IDH305 exhibits in vivo correlation of 2-HG reduction and efficacy in IDH1 mutant xenograft tumor model.
| M.Wt | 490.463 | |
| Formula | C23H22F4N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-4-((S)-1-fluoroethyl)-3-(2-(((S)-1-(4-methyl-2'-(trifluoromethyl)-[3,4'-bipyridin]-6-yl)ethyl)amino)pyrimidin-4-yl)oxazolidin-2-one |
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1. Cho YS, et al. ACS Med Chem Lett. 2017 Sep 18;8(10):1116-1121.
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