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Chemical Structure : IDO1 inhibitor VS-15
Catalog No.: PC-23215Not For Human Use, Lab Use Only.
IDO1 inhibitor VS-15 is a small molecule indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with cellular IC50 of 0.58 uM (Kyn production), not only inhibits the enzymatic but also the signaling-mediated functions of IDO1.
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IDO1 inhibitor VS-15 is a small molecule indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with cellular IC50 of 0.58 uM (Kyn production), not only inhibits the enzymatic but also the signaling-mediated functions of IDO1.
VS-15 selectively binds the heme-free form of IDO1, inhibits IDO1 enzymatic activity, and reduces the IDO1-mediated signaling pathway by negatively interfering with its partnership with SHPs and PI3K regulatory subunit p85 as well as with the IDO1 anchoring to the early endosomes in tumor cells.
VS-15 counteracts the TGF-β-mediated immunosuppressive phenotype in dendritic cells and reduces the level of inhibition of T cell proliferation by suppressive monocytes isolated from patients affected by pancreatic cancer.
VS-15 inhibits the enzymatic and nonenzymatic activities of IDO1 by binding to its apo-form.
| M.Wt | 493.57 | |
| Formula | C29H27N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Panfili E, et al. ACS Pharmacol Transl Sci. 2024 Sep 12;7(10):3056-3070.
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