IDO2 inhibitor 22

Chemical Structure : IDO2 inhibitor 22

Catalog No.: PC-23332Not For Human Use, Lab Use Only.

IDO2 inhibitor 22 is a selective iIndoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with IC50 of 112 nM and 411 nM for IDO2 and IDO1 respectively.

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Biological Activity

IDO2 inhibitor 22 is a selective indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with IC50 of 112 nM and 411 nM for IDO2 and IDO1 respectively.
IDO2 inhibitor 22 alleviated disease severity and reduced inflammatory cytokines in both the collagen-induced arthritis (CIA) mice model and adjuvant arthritis (AA) rat model.

Physicochemical Properties

M.Wt	541.37
Formula	C21H21BrN10O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-((1-(2-((4-(N-(3-Bromobenzyl)-N'-hydroxycarbamimidoyl)-1,2,5-oxadiazol-3-yl)amino)ethyl)-1H-1,2,3-triazol-4-yl)methyl)picolinamide

References

1. He G, et al. J Med Chem. 2022 Nov 10;65(21):14348-14365.

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