Catalog No.: PC-62828Not For Human Use, Lab Use Only.
IDX-375 is a novel potent, non-nucleoside, allosteric HCV NS5B RdRp inhibitor with IC50 of 15 nM and 5 nM for 1a-H77 HCV NS5B polymerase and 1b-J4 HCV NS5B polymerase, respectively.
IDX-375 is a novel potent, non-nucleoside, allosteric HCV NS5B RdRp inhibitor with IC50 of 15 nM and 5 nM for 1a-H77 HCV NS5B polymerase and 1b-J4 HCV NS5B polymerase, respectively.
IDX-375 has no activity against human cellular polymerases (>75 uM).
IDX-375 has an EC50 of 3 nM in HCV replicon luciferase assay.
IDX-375 displays excellent antiviral activity on the genotypes 1a and 1b, and a good PK profile in multiple animal models.
