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Chemical Structure : IDX899
Catalog No.: PC-60468Not For Human Use, Lab Use Only.
IDX899 (Fosdevirine, GSK 2248761) is a novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively.
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IDX899 (Fosdevirine, GSK 2248761) is a novel potent, selective HIV non-nucleoside reverse transcriptase inhibitor (NNRTI) with EC50 of 1, 1.3, 2.8 and 11 nM for WT, K103N, Y181C and K103N/Y181C, respectively.
IDX899 (Fosdevirine, GSK 2248761) shows substantial benefits in term of HIV mutant activities, physicochemical properties and pharmacological profile.
| M.Wt | 413.798 | |
| Formula | C20H17ClN3O3P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dousson C, et al. J Med Chem. 2016 Mar 10;59(5):1891-8.
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