IHCH-8110 | 5-HT2AR agonist | Probechem Biochemicals

Chemical Structure : IHCH-8110

IHCH-8110 (IHCH8110)

Catalog No.: PC-27530Not For Human Use, Lab Use Only.

IHCH-8110 is a potent, selective, non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist with Ki of 47.86 nM, inhibits CRC progression by activating 5-HT2AR on enteric glial cells.

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Biological Activity

IHCH-8110 is a potent, selective, non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist with Ki of 47.86 nM, inhibits CRC progression by activating 5-HT2AR on enteric glial cells.

IHCH-8110 acts as an agonist at both 5-HT2AR and 5-HT2CR in functional assays, including calcium flux and β-arrestin2 recruitment, also functions as a 5-HT2BR antagonist.

IHCH-8110 exhibits no detectable functional activity at other GPCR family 5-HT receptors or dopamine receptors.

IHCH-8110 suppresses CRC progression by enhancing CD8+ T cell antitumor functions.

IHCH-8110 targets enteric glial cells (EGCs) expressed on EGCs to inhibit tumor growth.

IHCH-8110 enhances the recruitment and polarization of CD8+ T cells by upregulating EGC-derived CXCL10 and IL-18.

IHCH-8110 sensitizes immune-cold CRC to anti-PD-1 therapy.

Physicochemical Properties

M.Wt	361.53
Formula	C21H35N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-(trans-4-aminocyclohexyl)-N′-[[4-(hexyloxy)phenyl]methyl]-N-methyl-

References

1. Wen Y, et al. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer. Cell. 2026 Aug 4:S0092-8674(26)00826-3.

IHCH-8110 (IHCH8110)

Biological Activity

Physicochemical Properties

References

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