IHMT-140 (IHMT140)

Chemical Structure : IHMT-140

Catalog No.: PC-27396Not For Human Use, Lab Use Only.

IHMT-140 is a dual-function agent that acts as a DDR1 inhibitor and a methuosis inducer, simultaneously remodels the tumor stromal ECM and activates excessive macropinocytosis, triggers methuosis in pancreatic cancer cells, inhibits tumor invasion and metastasis.

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Biological Activity

IHMT-140 is a dual-function agent that acts as a DDR1 inhibitor and a methuosis inducer, simultaneously remodels the tumor stromal ECM and activates excessive macropinocytosis, triggers methuosis in pancreatic cancer cells, inhibits tumor invasion and metastasis.

Physicochemical Properties

M.Wt	521.55
Formula	C27H26F3N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Methyl-3-(4-(5-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-pyrazol-1-yl)phenyl)-6-(trifluoromethyl)picolinamide

References

1. Wang B, et al. J Adv Res. 2026 Jul 28:S2090-1232(26)00594-1.

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IHMT-140 (IHMT140)

Biological Activity

Physicochemical Properties

References

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