IIP0943 | PLK1 inhibitor | Probechem Biochemicals

Chemical Structure : IIP0943

IIP0943 (IIP-0943)

Catalog No.: PC-24271Not For Human Use, Lab Use Only.

IIP0943 is a highly potent, selective polo-like kinase 1 (PLK1) inhibitor with IC50 of 5.1 nM, exhibits high selectivity for PLK1 compared to other PLKs.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

IIP0943 is a highly potent, selective polo-like kinase 1 (PLK1) inhibitor with IC50 of 5.1 nM, exhibits high selectivity for PLK1 compared to other PLKs.
IIP0943 also shows moderate inhibition against FAK (IC50=264 nM), 50-fold less potent than its inhibitory effect against PLK1.
IIP0943 inhibits cell proliferation inhibition with IC50 of 0.22 uM on HCT116 cell line.

Physicochemical Properties

M.Wt	504.61
Formula	C26H28N6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((2-((2-methoxy-5-(4-methylpiperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)oxy)benzo[b]thiophene-2-carboxamide

References

1. Xie W, et al. Nat Commun. 2025 Mar 10;16(1):2391.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

IIP0943 (IIP-0943)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.