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Chemical Structure : IK-930
CAS No.: 2563892-44-2
Catalog No.: PC-20406Not For Human Use, Lab Use Only.
IK-930 (IK930) is a selective, oral TEAD inhibitor that selectively inhibits TEAD-dependent transcription by directly blocking autopalmitoylation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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IK-930 (IK930) is a selective, oral TEAD inhibitor that selectively inhibits TEAD-dependent transcription by directly blocking autopalmitoylation.
IK-930 is inactive in a broad panel of kinases, receptors, and transporters, furthering evidence of selectivity.
IK-930 inhibits in vitro proliferation of Hippo pathway-deficient cancer cell lines, but not Hippo pathway wild type cells.
IK-930 demonstrates antitumor activity in mouse xenograft models with Hippo pathway genetic alterations.
IK-930 enhances apoptosis and in vivo antitumor activity in combination with EGFR and MEK inhibitors, respectively, in EGFR or KRAS mutated tumors.
| M.Wt | 424.44 | |
| Formula | C19H19F3N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenesulfonamide, N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[[4-(trifluoromethyl)phenyl]methyl]amino]- |
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1. Benjamin S. Amidon, et al. Cancer Res (2022) 82 (12_Supplement): 2156.
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