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Chemical Structure : IK1 inhibitor PA-6
CAS No.: 500715-03-7
Catalog No.: PC-35388Not For Human Use, Lab Use Only.
IK1 inhibitor PA-6 is an efficient, specific inhibitor of inward rectifier current (IK1), blocks KIR2.x currents of human and mouse with IC50 of 12-15 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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IK1 inhibitor PA-6 is an efficient, specific inhibitor of inward rectifier current (IK1), blocks KIR2.x currents of human and mouse with IC50 of 12-15 nM.
PA-6 does not affect INav1.5, ICa-L, IKv4.3, IKv11.1, and IKv7.1/minK currents at 200 nM.
PA-6 inhibits the inward (50 nM 40%; 100 nM 59%; 200 nM 77%) and outward (50 nM 40%; 100 nM 76%; 200 nM 100%) components of IK1 in isolated canine adult-ventricular cardiomyocytes.
PA-6 demonstrates higher efficiency and specificity to KIR2.x-mediated current than the antiprotozoal drug pentamidine.
| M.Wt | 492.623 | |
| Formula | C31H32N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane |
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1. Ji Y, et al. Br J Pharmacol. 2017 Aug;174(15):2576-2590.
2. Ji Y, et al. J Biomed Sci. 2017 Jul 15;24(1):44.
3. Takanari H, et al. Cardiovasc Res. 2013 Jul 1;99(1):203-14.
4. Hoeker GS, et al. Physiol Rep. 2017 Jan;5(1). pii: e13120.
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