Chemical Structure : IKZF2 degrader 55
CAS No.:
2983841-00-3
IKZF2 degrader 55
Catalog No.: PC-25388Not For Human Use, Lab Use Only.
IKZF2 degrader 55 is a potent, selective IKZF2 degrader with DC50 of 1.8 nM by FACS assay in the Jurkat cells, Dmax=92%, shows minimal off-target activity against IMiD neo-substrates.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IKZF2 degrader 55 is a potent, selective IKZF2 degrader with DC50 of 1.8 nM by FACS assay in the Jurkat cells, Dmax=92%, shows minimal off-target activity against IMiD neo-substrates.
IKZF2 degrader 55 does not degrade a number of other neo-substrates, such as IKZF3, SALL4, and GSPT1.
IKZF2 degrader 55 displays moderate degradation against SALL4 (DC50 = 9 nM, Dmax = 57%).
IKZF2 degrader 55 at 10 and 30 mg/kg depleted IKZF2 protein by 88 and 79%, respectively, in spleen tissue, and 79 and 83%, respectively, in thymus tissue at the 6 h time-point.
Physicochemical Properties
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M.Wt
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509.97
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Formula
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C26H25ClFN5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(5-(5-Chloro-1-methyl-4-(pyrrolidin-1-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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References
1. Zhang X, et al. J Med Chem. 2025 Aug 21. doi: 10.1021/acs.jmedchem.5c00668.
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