Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : IMA-1
Catalog No.: PC-72818Not For Human Use, Lab Use Only.
IMA-1 (ALOX12-ACC1 inhibitor IMA-1) is a small molecule that interrupt the arachidonate 12-lipoxygenase (ALOX12)-acetyl-CoA carboxylase 1 (ACC1) interaction.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
IMA-1 is a small molecule that interrupt the arachidonate 12-lipoxygenase (ALOX12)-acetyl-CoA carboxylase 1 (ACC1) interaction.
IMA-1 markedly blocked diet-induced NASH progression in both male mice and Cynomolgus macaque therapeutic models.
The anti-NASH efficacy of IMA-1 was comparable to ACC inhibitor in both species.
IMA-1 directly binds to a pocket in ALOX12 proximal to its ACC1-interacting surface instead of inhibiting ALOX12 lipoxygenase activity.
IMA-1 treatment did not elicit hyperlipidemia, a known side effect of direct inhibition of ACC enzymatic activity, in both mice and macaques.
| M.Wt | 617.644 | |
| Formula | C27H27N3O10S2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Xiao-Jing Zhang, et al. Sci Transl Med. 2021 Dec 15;13(624):eabg8116.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
