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Chemical Structure : IMB5476
Catalog No.: PC-72275Not For Human Use, Lab Use Only.
IMB5476 (IMB 5476) is a nitrobenzoate microtubule inhibitor, exerts broad-spectrum cytotoxicity against various human tumor cell lines (NCI-H460, IC50=144 nM).
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IMB5476 (IMB 5476) is a nitrobenzoate microtubule inhibitor, exerts broad-spectrum cytotoxicity against various human tumor cell lines (NCI-H460, IC50=144 nM).
IMB5476 inhibits purified tubulin polymerization in vitro, binds to tubulin at the colchicine pocket.
IMB5476 induced cell death by mitotic catastrophe and apoptosis, disrupted microtubule networks in cells and arrested cell cycle at G2/M phase.
IMB5476 is a poor substrate of P-glycoprotein and exhibited potent cytotoxicity against drug-resistant tumor cells.
IMB5476 inhibited angiogenesis in vitro, also inhibited the growth of drug-resistant KBV200 xenografts in mice.
| M.Wt | 416.818 | |
| Formula | C19H17ClN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yan-Bo Zheng, et al. Eur J Pharmacol. 2022 Feb 8;919:174802.
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