Catalog No.: PC-20280Not For Human Use, Lab Use Only.
IMMH-010 maleate (YPD-30) is an ester prodrug of YPD-29B, a high potent PD-L1 inhibitor (IC50=0.08 pM), YPD-30 is a potent PD-L1 inhibitor with IC50 of 45.2 nM in HTRF assays.
IMMH-010 maleate (YPD-30) is an ester prodrug of YPD-29B, a high potent PD-L1 inhibitor (IC50=0.08 pM), YPD-30 is a potent PD-L1 inhibitor with IC50 of 45.2 nM in HTRF assays.
YPD-30 is an orally bioavailable prodrug for YPD-29B with significantly higher bioavailability than YPD-29B.
YPD-30 exhibits antitumor activity by inhibiting PD-L1 in vivo, significantly increased T cell infiltration by increasing CD3 and CD8 expression in hPD-L1 MC38 xenograft tumor tissue, markedly decreased hPD-L1 expression.
