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IMPDH2-IN-5

Chemical Structure : IMPDH2-IN-5

CAS No.: 2119603-25-5

IMPDH2-IN-5 (IMPDH2 inhibitor)

Catalog No.: PC-70215Not For Human Use, Lab Use Only.

IMPDH2-IN-5 is a potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with IC50 of 620 nM (inhibition of NO production).

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    Biological Activity

    IMPDH2-IN-5 is a potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with IC50 of 620 nM (inhibition of NO production).
    IMPDH2-IN-5 is a Sappanone A derivative.

    Physicochemical Properties

    M.Wt 302.257
    Formula C16H11FO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-3-(3,4-dihydroxybenzylidene)-5-fluoro-7-hydroxychroman-4-one

    References

    1. Liao LX, et al. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5986-E5994.

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