Chemical Structure : IMPDH2 inhibitor Comp-10
CAS No.:
907546-24-1
IMPDH2 inhibitor Comp-10
Catalog No.: PC-25669Not For Human Use, Lab Use Only.
IMPDH2 inhibitor Comp-10 is a specific, allosteric inhibitor of Inosine monophosphate dehydrogenase-2 (IMPDH2) with IC50 of 260 nM, disrupts R/R formation, and prevents tumor cell proliferation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IMPDH2 inhibitor Comp-10 is a specific, allosteric inhibitor of Inosine monophosphate dehydrogenase-2 (IMPDH2) with IC50 of 260 nM, disrupts R/R formation, and prevents tumor cell proliferation.
Comp-10 decreases IMPDH1/2 protein levels, blocks filament (rod/ring) formation, and inhibits the growth of ALK and BTK inhibitor-resistant lymphoma cells.
Comp-10 shows (1 uM) potent inhibition (>93%) of recombinant human IMPDH2 activity.
Comp-10 downregulates IMPDH1/2 expression and prevents filament (rod/ring) formation in ALCL and MCL models.
Comp-10 inhibits proliferation and colony formation in ALK-positive lymphoma cells.
Physicochemical Properties
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M.Wt
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441.28
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Formula
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C18H21BrN2O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-bromo-5,8-dihydroxy-7-(4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-yl)naphthalene-1,4-dione
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References
1. Pattabiraman N, et al. Cancers (Basel). 2025 Oct 21;17(20):3389.
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