Catalog No.: PC-42154Not For Human Use, Lab Use Only.
A small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=26 uM).
IMR-1 is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=26 uM).
IMR-1 non-covalently binds to intracellular domain of Notch (NICD) with Kd of 11 uM, inhibits Notch target gene transcription and selectively suppresses colony formation of Notch-dependent cell lines。
IMR-1 dramatically inhibits tumor growth in a patient-derived tumor xenograft model.
