Catalog No.: PC-42155Not For Human Use, Lab Use Only.
IMR-1A is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=0.5 uM).
IMR-1A is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=0.5 uM).
IMR-1A non-covalently binds to intracellular domain of Notch (NICD) with Kd of 2.9 uM.
IMR-1A inhibits Notch target gene transcription and selectively suppresses colony formation of Notch-dependent cell lines.
IMR-1A is the acid metabolite of IMR-1.
