Chemical Structure : IMR-1A
CAS No.: 331862-41-0
Catalog No.: PC-42155Not For Human Use, Lab Use Only.
IMR-1A is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=0.5 uM).
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IMR-1A is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=0.5 uM).
IMR-1A non-covalently binds to intracellular domain of Notch (NICD) with Kd of 2.9 uM.
IMR-1A inhibits Notch target gene transcription and selectively suppresses colony formation of Notch-dependent cell lines.
IMR-1A is the acid metabolite of IMR-1.
| M.Wt | 325.3601 | |
| Formula | C13H11NO5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Acetic acid, 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]- |
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1. Astudillo L, et al. Cancer Res. 2016 Jun 15;76(12):3593-603.
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