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INCB13739

Chemical Structure : INCB13739

CAS No.: 872506-67-7

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INCB13739 (INCB-13739;INCB 13739)

Catalog No.: PC-35575Not For Human Use, Lab Use Only.

INCB13739 (INCB-13739) is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) with high seelctivity over other dehydrogenases, glucocorticoid and mineralocorticoid receptors..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

INCB13739 (INCB-13739) is a potent, selective, oral 11β-HSD1 inhibitor (IC50=1.1 nM) with high seelctivity over other dehydrogenases, glucocorticoid and mineralocorticoid receptors.

Physicochemical Properties

M.Wt 398.946
Formula C19H27ClN2O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S)-1-[(3-Chloro-2-methylphenyl)sulfonyl]-N-cyclohexyl-3-piperidinecarboxamide

References

1. Rosenstock J, et al. Diabetes Care. 2010 Jul;33(7):1516-22.

2. Ge R, et al. Curr Med Chem. 2010;17(5):412-22.

3. Anagnostis P, et al. Metabolism. 2013 Jan;62(1):21-33.

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