IND125 |CAS: 2650085-35-9 Probechem Biochemicals

Chemical Structure : IND125

IND125 (IND-125;IND125 )

Catalog No.: PC-60645Not For Human Use, Lab Use Only.

IND125 is a potent, brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.

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Biological Activity

IND125 is a potent, brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.
IND125 prolongs the lives of mice expressing a chimeric human/mouse PrP transgene inoculated with Creutzfeldt-Jakob disease prions.

Physicochemical Properties

M.Wt	386.429
Formula	C21H14N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(oxazol-5-yl)phenyl)-4-(3-phenylisoxazol-5-yl)thiazol-2-amine

References

1. Giles K, et al. J Pharmacol Exp Ther. 2015 Oct;355(1):2-12.

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IND125 (IND-125;IND125 )

Biological Activity

Physicochemical Properties

References

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