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IND125

Chemical Structure : IND125

CAS No.: 2650085-35-9

IND125 (IND-125;IND125 )

Catalog No.: PC-60645Not For Human Use, Lab Use Only.

IND125 is a potent, brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IND125 is a potent, brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.
    IND125 prolongs the lives of mice expressing a chimeric human/mouse PrP transgene inoculated with Creutzfeldt-Jakob disease prions.

    Physicochemical Properties

    M.Wt 386.429
    Formula C21H14N4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(4-(oxazol-5-yl)phenyl)-4-(3-phenylisoxazol-5-yl)thiazol-2-amine

    References

    1. Giles K, et al. J Pharmacol Exp Ther. 2015 Oct;355(1):2-12.

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