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Chemical Structure : INU-101
Catalog No.: PC-35573Not For Human Use, Lab Use Only.
INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rat, and human 11β-HSD1, respectively.
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INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rat, and human 11β-HSD1, respectively.
INU-101 displays good selectivity for human 11β-HSD1 over 11β-HSD2 (IC50>10 uM).
INU-101 significantly inhibits the 11β-HSD1 activity in mice 3T3-L1 adipocytes (IC50=9.1 nM), enhances insulin sensitivity and lowers the fasting blood glucose level in KKAy mice, ob/ob mice and ZDF rats after oral administration, decreases the body weight and ameliorates an improved lipid profile in the diabetic mouse model.
| M.Wt | 437.53 | |
| Formula | C21H28FN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hong SP, et al. Eur J Pharmacol. 2018 Aug 7. pii: S0014-2999(18)30450-3.
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