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INX-08189

Chemical Structure : INX-08189

CAS No.: 1234490-83-5

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INX-08189 (INX08189;BMS-986094)

Catalog No.: PC-60009Not For Human Use, Lab Use Only.

INX-08189 (BMS-986094) is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

INX-08189 (BMS-986094) is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.
INX-08189 (BMS-986094) inhibits viral replication with EC50 of 35 nM, inhibits mutant NS5b S282T mutant replicon with EC90 of 344 nM; orally active.

Physicochemical Properties

M.Wt 658.649
Formula C30H39N6O9P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Neopentyl ((((2R,3R,4R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate

References

1. McGuigan C, et al. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4850-4.

2. Vernachio JH, et al. Antimicrob Agents Chemother. 2011 May;55(5):1843-51.

3. Ehteshami M, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4659-69.

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