Chemical Structure : IOR-160
CAS No.:
2421119-78-8
IOR-160
(IOR160)
Catalog No.: PC-25109Not For Human Use, Lab Use Only.
IOR-160 is a potent dual inhibitor of casein kinase 2 (CK2) and HDAC with IC50 of 1.7 nM for CK2 and 3.3/24.0/3.9/13.0 nM for HDAC1/2/3/6 respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IOR-160 is a potent dual inhibitor of casein kinase 2 (CK2) and HDAC with IC50 of 1.7 nM for CK2 and 3.3/24.0/3.9/13.0 nM for HDAC1/2/3/6 respectively.
IOR-160 exhibits highly potent inhibition of CK2 and HIPK2 (less than 10% of remanent activity at 0.5 μM), while showing moderate to low inhibition of DYRK1A, CLK2, Pim-1, Mnk2, DRAK1, and TrkA (from 18% to 65%).
IOR-160 exhibits potent inhibitory activity (in the nanomolar range) against HDAC1, HDAC2, HDAC3, and HDAC6, while shows significantly less potency for HDAC8 (in the micromolar range).
IOR-160 results in reduced MDA-MB-231 tumor growth in xenograft model.
Physicochemical Properties
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M.Wt
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510.47
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Formula
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C23H25F3N4O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[[8-(hydroxyamino)-8-oxooctyl]amino]-, 2,2,2-trifluoroacetate (1:1)
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References
1. Irene Ortín, et al. ACS Pharmacol Transl Sci. 2025 Jul 1;8(7):2093-2105.
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