Chemical Structure : IP2015
CAS No.:
1320346-14-2
IP2015
(IPED2015, Pudafensine, NS18313)
Catalog No.: PC-22148Not For Human Use, Lab Use Only.
IP2015 (IPED2015, Pudafensine, NS18313) is a novel monoamine transport inhibitor with IC50 of 9.5, 72.0 and 3.8 nM for hSET, hNAT and hDAT respectively, inhibits dopamine uptake and binds to DAT.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IP2015 (IPED2015, Pudafensine, NS18313) is a novel monoamine transport inhibitor with IC50 of 9.5, 72.0 and 3.8 nM for hSET, hNAT and hDAT respectively, inhibits dopamine uptake and binds to DAT.
IP2015 inhibits uptake, ex vivo, of 5-HT and noradrenaline to SERT and NET with ED50 values = 49 and >45 mg·kg−1, respectively.
IP2015 (0.1-10 mg/kg) induces spontaneous erections in rats.
The PDE5 inhibitor sildenafil further enhanced the IP2015-mediated increase in intracavernosal pressure.
IP2015 also increases the number of erections in type 2 diabetic db/db mice, increases penile pressure, and in corpus cavernosum strips, and induces concentration-dependent relaxations.
Physicochemical Properties
|
M.Wt
|
301.34
|
|
Formula
|
C17H19NO4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
7-[(exo-8-azabicyclo[3.2.1]octan-3-yl)oxy]-3-methoxy-chromen-2-one
|
References
1. Comerma-Steffensen S, et al. Br J Pharmacol. 2024 Apr 11. doi: 10.1111/bph.16362.
Contact Us
sales@probechem.com
